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University of Medicine and Dentistry of New Jersey

University of Medicine and Dentistry of New Jersey

University of Medicine and Dentistry of New Jersey

Weill Cornell Medical College
Patients with other cancer types who carry BRCA1 mutations. We used data from The Cancer Genome Atlas (TCGA) to examine the percentage of patients with other tumor types who show deleterious mutations (missense, nonsense, copy-number, and structural variations) in their BRCA1 gene. We found that ovarian and breast cancers are only 2 of 21 total cancer types likely to be associated with relevant mutations in BRCA1, as determined by TCGA. (Rosenfeld and Mason Genome Medicine 2013 5:27 doi:10.1186/gm431)

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